Definition: Infantile myofibromatosis is a mesenchymal disorder of infancy characterized by the formation of tumors in skin, subcutaneous tissue, muscle, bone and viscera.
Prevalence: Until now 175 cases of Infantile Myofibromatosis have been published in the English literature. The incidence of soft tissue tumors in newborns has been estimated to be 1 in 150,000 live births.
Etiology: Unknown. An association to excess estrogen production has been proposed.
Diagnosis: The diagnosis relies on identification of solid tumor masses of variable size at different locations, which are well circumscribed and sometimes well encapsulated.