Hypothalamic hamartomas present as a suprasellar solid mass within the thalami region of the brain.
Gliomas, germ cell tumors. Hypothalamic hamartoblastomas are part of the Pallister-Hall syndrome.
Hypoplasia of the olfactory bulbs, absence of the pituitary gland, cardiac and renal anomalies, imperforate anus, craniofacial anomalies, syndactyly and short metacarpal.
The children with the hypothalamic hamartoma suffer with seizures, visual changes and precocious puberty in both sexes (3, 4).
Antiepileptic drugs and gonadotropin-releasing hormone agonists are used in treatment of the accompanying symptoms of the hypothalamic hamartomas. (3, 4).
1. Poussaint, Tina Young. Magnetic resonance imaging of pediatric brain tumors: State of the Art. Topics in magnetic resonance imaging. Pediatric Neuroradiology, Part I, Vol 12(6), 411-433. December 2001.
2. Cheng Kan, Swamura Yukata, Yamauchi T et all. Asyntomatic large hypothalamic hamartoma associated with polydactilia in an adult. Neurosurgery, 32(3):458-460, March 1993.
3. Feuillan P, Jones JV, Barnes K et all. Reproductive axis after discontinuation of gonadotropin releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those idiopathic precocious puberty. J. Clin Endocrinol and metabolism. Vol 84, Nº 1, 44-49.1999.
4. Feuillan P, Jones JV, Barnes K et all. Boy with precocious puberty due to hypothalamic hamartoma: reproductive axis after discontinuation of gonadotropin releasing hormone analog therapy. J. Clin Endocrinol and metabolism. Vol 85, Nº 11, 4036-4038.2000.