Yes.. where are the ribs ???
Associated anomalies: Other findings include:
· Mental retardation in some patients, others may have normal intelligence.
· Cartilage or bone may be abnormal in other areas such as trachea, hip and elbow.
· The combination of micrognathia, glossoptosis and "flat chestâ€ causes severe respiratory distress.
Complications: Respiratory distress, respiratory infection, failure to thrive, speech delay, hearing loss.
Ear, patella, short stature syndrome: also has slender ribs and micrognathia but the long bones are short. However, microtia is a distinguishing feature of the syndrome.
Campomelic dysplasia In campomelic dysplasia the ribs are normally ossified but the fetus may be missing a pair of rib. The designation campomelic (or camptomelic) dwarfism, comes from the bowing of the legs, especially the tibias. The scapulas are very small and the pelvis and spine show changes. The inferior part of the scapula is hypoplastic. Cleft palate, micrognathia, flat face, and hypertelorism are also features. Most patients die in the neonatal period of respiratory distress.
Prognosis: Mortality in early infancy is high: 10 out of 24 cases, died before the age of 3 months. Yet, survival has extended to adulthood. All survivors showed growth disturbances.
Recurrence risk: Mendelian inheritance
Management: Intensive care for respiratory distress, feeding difficulty and infection. Cleft palate repair, special education and hearing aids for hearing loss.
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 R. Hennekam, R. C. M.; Goldschmeding. Complete absence of rib ossification, micrognathia and ear anomalies: extreme expression of cerebro-costo-mandibular syndrome? Europ. J. Hum. Genet. 6: 71-74, 1998.
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 ML Buyse (Ed.) Cerebro-costo-mandibular syndrome Birth defects encyclopedia p.302